THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS
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Case Western Reserve University School of Graduate Studies / OhioLINK
2013
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=case1346854771 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-case13468547712021-08-03T05:19:44Z THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS Davis, Rohit Michael Biology Genetics Health Care Marketing Pharmaceuticals Muscular Dystrophy Follistatin Market feasibility Commercialization Orthopedic application Muscular Dystrophies represent a group of inherited disorders that are characterized by muscle weakness and loss of muscle tissue with the symptoms generally worsening over time. Most therapies that have been invented and researched until now have aimed at targeting dystrophin which is the gene that is defective in muscular dystrophy patients. However, there is substantial clinical evidence that the upregulation of follistatin results in better muscle growth and strengthening. Moreover, the use of adeno-associated viruses ensures the efficient, specific delivery of the transgenes to the muscle that requires it. Furthermore, the alternatively spliced variant of Follistatin used in the therapy ensures the prevention of any off-target effects that is a major concern and hurdle in gene therapy development. In this thesis, an attempt has been made to assess the technology for its scientific and commercial feasibility in addition to assessing possible therapeutic applications outside the realm of muscular dystrophies. 2013-03-07 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1346854771 http://rave.ohiolink.edu/etdc/view?acc_num=case1346854771 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center. |
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NDLTD |
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English |
| sources |
NDLTD |
| topic |
Biology Genetics Health Care Marketing Pharmaceuticals Muscular Dystrophy Follistatin Market feasibility Commercialization Orthopedic application |
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Biology Genetics Health Care Marketing Pharmaceuticals Muscular Dystrophy Follistatin Market feasibility Commercialization Orthopedic application Davis, Rohit Michael THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS |
| author |
Davis, Rohit Michael |
| author_facet |
Davis, Rohit Michael |
| author_sort |
Davis, Rohit Michael |
| title |
THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS |
| title_short |
THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS |
| title_full |
THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS |
| title_fullStr |
THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS |
| title_full_unstemmed |
THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS |
| title_sort |
assessment and development of follistatin as a gene therapy and its potential orthopedic applications |
| publisher |
Case Western Reserve University School of Graduate Studies / OhioLINK |
| publishDate |
2013 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=case1346854771 |
| work_keys_str_mv |
AT davisrohitmichael theassessmentanddevelopmentoffollistatinasagenetherapyanditspotentialorthopedicapplications AT davisrohitmichael assessmentanddevelopmentoffollistatinasagenetherapyanditspotentialorthopedicapplications |
| _version_ |
1719418561938587648 |