FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS

FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS

Bibliographic Details
Main Author: Ontaneda, Daniel
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2012
Subjects:
Neurology
multiple sclerosis
diffusion tensor imaging
natalizumab
brain integrity
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1341344380
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case13413443802021-08-03T05:34:43Z FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS Ontaneda, Daniel Neurology multiple sclerosis diffusion tensor imaging natalizumab brain integrity <p>IntroductionDiffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) measure of brain tissue integrity. Little is known regarding the long term longitudinal evolution of lesional and non-lesional tissue using DTI in multiple sclerosis (MS).</p><p>MethodsTwenty-one patients with MS starting natalizumab were imaged for 48 months. Gadolinium-enhancing lesions at baseline scan (GAD), chronic T2 lesions, and normal-appearing white matter (NAWM) were followed longitudinally. Within each region of interest, the average value of longitudinal diffusivity (LD) and transverse diffusivity (TD) was derived using Analysis of Functional Neuroimaging Software (AFNI). The longitudinal trend in LD and TD was estimated using a mixed-model regression analysis.</p><p>ResultsSignificant increases over time were observed for TD (p=0.04) and LD (p <0.0001) in GAD tissue. A significant increase in LD (p<0.0001) with stability of TD was seen in chronic T2 lesions. No significant differences were observed in NAWM. </p><p>ConclusionsIncreases in TD over 4 years suggest ongoing demyelination in GAD lesions. An increase in LD in both GAD and T2 lesions is a new finding and may relate to the complex evolution of brain tissue lesions. NAWM remained stable over 4 years.</p> 2012-08-27 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1341344380 http://rave.ohiolink.edu/etdc/view?acc_num=case1341344380 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Neurology
multiple sclerosis
diffusion tensor imaging
natalizumab
brain integrity
spellingShingle Neurology
multiple sclerosis
diffusion tensor imaging
natalizumab
brain integrity
Ontaneda, Daniel
FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS
author Ontaneda, Daniel
author_facet Ontaneda, Daniel
author_sort Ontaneda, Daniel
title FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS
title_short FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS
title_full FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS
title_fullStr FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS
title_full_unstemmed FOUR-YEAR EVOLUTION OF BRAIN TISSUE INTEGRITY USING DIFFUSION TENSOR IMAGING IN MULTIPLE SCLEROSIS
title_sort four-year evolution of brain tissue integrity using diffusion tensor imaging in multiple sclerosis
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2012
url http://rave.ohiolink.edu/etdc/view?acc_num=case1341344380
work_keys_str_mv AT ontanedadaniel fouryearevolutionofbraintissueintegrityusingdiffusiontensorimaginginmultiplesclerosis
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