Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies

Bibliographic Details
Main Author:	Evans, Sarah Frances
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2012
Subjects:	Biomechanics Biomedical Engineering Biomedical Research periosteum mechanobiology tissue level mechanical properties perioisteum derived cells permeability
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case13316469022021-08-03T05:34:26Z Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies Evans, Sarah Frances Biomechanics Biomedical Engineering Biomedical Research periosteum mechanobiology tissue level mechanical properties perioisteum derived cells permeability The periosteum serves as a stabilizing boundary membrane to the bone it envelopes and contains mechanosensitive progenitor cells capable of promoting new bone formation. Knowledge of the structure-function relationships underlying the dynamic mechanical and regenerative properties of the periosteum is lacking. The following work investigates the structure-function relationships present in periosteum at both the tissue and cellular level. At the tissue level, periosteum permeability is characterized and found to exhibit barrier membrane properties. Subsequently, cell scale studies investigate the molecular characteristics of periosteum cells responsible for enabling tissue-level barrier membrane properties. Lastly, a biomimetic membrane system for investigating cell-cell adhesions of periosteum cells is developed. Culture of periosteum cells on the model membrane system results in signs of early osteogenic lineage commitment. Characterization of structure-function relationships in periosteum across multiple lengths scales provides knowledge valuable for the development of predictive computational models and tissue engineered periosteal replacement membranes. 2012-05-22 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902 http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Biomechanics Biomedical Engineering Biomedical Research periosteum mechanobiology tissue level mechanical properties perioisteum derived cells permeability
spellingShingle	Biomechanics Biomedical Engineering Biomedical Research periosteum mechanobiology tissue level mechanical properties perioisteum derived cells permeability Evans, Sarah Frances Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies
author	Evans, Sarah Frances
author_facet	Evans, Sarah Frances
author_sort	Evans, Sarah Frances
title	Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies
title_short	Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies
title_full	Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies
title_fullStr	Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies
title_full_unstemmed	Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies
title_sort	top down and bottom up approaches to elucidating multiscale periosteal mechanobiology: tissue level and cell scale studies
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2012
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1331646902
work_keys_str_mv	AT evanssarahfrances topdownandbottomupapproachestoelucidatingmultiscaleperiostealmechanobiologytissuelevelandcellscalestudies
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Top Down and Bottom Up Approaches to Elucidating Multiscale Periosteal Mechanobiology: Tissue Level and Cell Scale Studies

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