Negative Regulation of Type I Interferon Induction in Dendritic Cells

Negative Regulation of Type I Interferon Induction in Dendritic Cells

Bibliographic Details
Main Author: Liu, Yi
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2011
Subjects:
Immunology
type I interferon
dendritic cells
pattern recognition receptors
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1310149509
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case13101495092021-08-03T05:34:10Z Negative Regulation of Type I Interferon Induction in Dendritic Cells Liu, Yi Immunology type I interferon dendritic cells pattern recognition receptors Type I interferon (IFN) regulates innate and adaptive immunity. It protects host cells against viral infection. Many microorganisms have evolved successful mechanisms to inhibit host type I IFN response. Excessive type I IFN is associated with autoimmune diseases such as systemic lupus erythematosus (SLE). Studying the negative regulation of type I IFN will help understand the pathogenesis of infectious diseases and potential therapeutic control of type I IFN in SLE. In murine bone marrow derived dendritic cells (DCs), we found two mechanisms that can inhibit type I IFN production in DCs. First, CpG-B ODNs, previously known as weak IFN inducers, globally inhibit type I IFN production by multiple Toll-like receptor (TLR)-dependent and –independent pathways. It involves transcriptional regulation of first-wave type I IFN induction downstream of multiple receptors by inhibiting binding of IRF1 and chromatin remodeling at the IFN-β and IFN-α4 promoters. Second, M. tuberculosis and TLR2 agonists specifically inhibit MyD88-dependent (TLR7/TLR9-induced) type I IFN induction. The inhibition is mediated through a new protein synthesis –independent direct intracellular mechanism that is correlated with rapid depletion of IRAK1. Overall, further investigation of these mechanisms may help us understand the role of type I IFN in infections and vaccines when multiple TLR agonists are present and may provide therapeutic targets for controlling type I IFN production in vivo. 2011 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1310149509 http://rave.ohiolink.edu/etdc/view?acc_num=case1310149509 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Immunology
type I interferon
dendritic cells
pattern recognition receptors
spellingShingle Immunology
type I interferon
dendritic cells
pattern recognition receptors
Liu, Yi
Negative Regulation of Type I Interferon Induction in Dendritic Cells
author Liu, Yi
author_facet Liu, Yi
author_sort Liu, Yi
title Negative Regulation of Type I Interferon Induction in Dendritic Cells
title_short Negative Regulation of Type I Interferon Induction in Dendritic Cells
title_full Negative Regulation of Type I Interferon Induction in Dendritic Cells
title_fullStr Negative Regulation of Type I Interferon Induction in Dendritic Cells
title_full_unstemmed Negative Regulation of Type I Interferon Induction in Dendritic Cells
title_sort negative regulation of type i interferon induction in dendritic cells
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=case1310149509
work_keys_str_mv AT liuyi negativeregulationoftypeiinterferoninductionindendriticcells
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