Affinity-Based Delivery of Retinoids

Affinity-Based Delivery of Retinoids

Bibliographic Details
Main Author: Vesole, Steven Michael
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2011
Subjects:
Biomedical Engineering
AMD
drug delivery
cyclodextrin
hydrogel
retinoid
tunable delivery
extended delivery
ocular delivery
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case13101383962021-08-03T05:34:10Z Affinity-Based Delivery of Retinoids Vesole, Steven Michael Biomedical Engineering AMD drug delivery cyclodextrin hydrogel retinoid tunable delivery extended delivery ocular delivery Age-related Macular Degeneration (AMD) is a debilitating disease that deteriorates central vision. Retinoid analogues have shown promise in treating AMD and other ocular conditions by circumventing a faulty phototransduction pathway found in unhealthy cells. A cyclodextrin (CD) molecule is a well-known cyclic oligosaccharide that has been used in the food, pharmaceutical, and chemical industries for its unique chemical structure containing a hydrophobic cavity that can increase the solubility of hydrophobic molecules. This hydrophobic interaction, hereby deemed an affinity inclusion complex, is exploited in several hydrogel drug delivery formulations; sustained release was maintained for more than 30 days. Affinity complexes are also explored through spectroscopic analysis, mathematical modeling, and simulation. 2011-09-19 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396 http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomedical Engineering
AMD
drug delivery
cyclodextrin
hydrogel
retinoid
tunable delivery
extended delivery
ocular delivery
spellingShingle Biomedical Engineering
AMD
drug delivery
cyclodextrin
hydrogel
retinoid
tunable delivery
extended delivery
ocular delivery
Vesole, Steven Michael
Affinity-Based Delivery of Retinoids
author Vesole, Steven Michael
author_facet Vesole, Steven Michael
author_sort Vesole, Steven Michael
title Affinity-Based Delivery of Retinoids
title_short Affinity-Based Delivery of Retinoids
title_full Affinity-Based Delivery of Retinoids
title_fullStr Affinity-Based Delivery of Retinoids
title_full_unstemmed Affinity-Based Delivery of Retinoids
title_sort affinity-based delivery of retinoids
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=case1310138396
work_keys_str_mv AT vesolestevenmichael affinitybaseddeliveryofretinoids
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