A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide

A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide

Bibliographic Details
Main Author: Khasnis, Atul Ashok
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2011
Subjects:
Economics
Medicine
granulomatosis with polyangiitis
Wegener's
cost effectiveness
cyclophosphamide
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1307639641
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case13076396412021-08-03T05:34:10Z A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide Khasnis, Atul Ashok Economics Medicine granulomatosis with polyangiitis Wegener's cost effectiveness cyclophosphamide OBJECTIVE: To assess the cost-effectiveness of weekly compared to monthly white blood count (WBC) monitoring in patients with severe granulomatosis with polyangiitis (GPA) receiving oral cyclophosphamide (CYC). METHODS: The two CBC monitoring approaches for surveillance of leukopenia and its consequences were compared using a decision analysis model. The prevalence of leukopenia, infections, and outcomes were obtained from an existing registry and published reports. Costs were in dollars (2010) and effectiveness as quality-adjusted life-years (QALYs) gained.RESULTS: The expected utility of weekly CBC monitoring of these patients for leukopenia is 18.74 QALYs versus 18.52 QALYs with monthly CBC. The expected gain is 0.22 QALYs and incurs $489 lower cost per patient. The weekly CBC strategy mostly dominated the monthly CBC strategy. CONCLUSION: Weekly CBC monitoring is cost-effective for prevention of severe leukopenia and severe infections in patients on CYC for severe GPA. 2011 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1307639641 http://rave.ohiolink.edu/etdc/view?acc_num=case1307639641 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Economics
Medicine
granulomatosis with polyangiitis
Wegener's
cost effectiveness
cyclophosphamide
spellingShingle Economics
Medicine
granulomatosis with polyangiitis
Wegener's
cost effectiveness
cyclophosphamide
Khasnis, Atul Ashok
A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide
author Khasnis, Atul Ashok
author_facet Khasnis, Atul Ashok
author_sort Khasnis, Atul Ashok
title A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide
title_short A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide
title_full A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide
title_fullStr A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide
title_full_unstemmed A Cost Effectiveness Analysis Of Weekly Complete Blood Count Monitoring For Leukopenia In Patients With Granulomatosis with Polyangiitis (GPA) On Cyclophosphamide
title_sort cost effectiveness analysis of weekly complete blood count monitoring for leukopenia in patients with granulomatosis with polyangiitis (gpa) on cyclophosphamide
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=case1307639641
work_keys_str_mv AT khasnisatulashok acosteffectivenessanalysisofweeklycompletebloodcountmonitoringforleukopeniainpatientswithgranulomatosiswithpolyangiitisgpaoncyclophosphamide
AT khasnisatulashok costeffectivenessanalysisofweeklycompletebloodcountmonitoringforleukopeniainpatientswithgranulomatosiswithpolyangiitisgpaoncyclophosphamide
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