Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes

Bibliographic Details
Main Author:	Huang, Pinchia
Language:	English
Published:	Case Western Reserve University School of Graduate Studies / OhioLINK 2009
Subjects:	African Americans Biomedical Research Genetics Health Care Minority and Ethnic Groups Obstetrics prental screeening test quad screens first trimester screens second trimester screens first check pregnancy complications adverse pregnancy outcomes obstetric complications African American pregnancy intrauterine growth retardation
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-case12476278142021-08-03T05:33:16Z Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes Huang, Pinchia African Americans Biomedical Research Genetics Health Care Minority and Ethnic Groups Obstetrics prental screeening test quad screens first trimester screens second trimester screens first check pregnancy complications adverse pregnancy outcomes obstetric complications African American pregnancy intrauterine growth retardation Studies have shown that abnormal levels of individual prenatal screening markers are associated with an increased risk for obstetric complications unrelated to aneuploidy. The purpose of this descriptive cohort medical record review of pregnant patients was to examine the association between risk estimates or marker patterns and pregnancy complications. Prenatal screening and obstetric outcome data were analyzed for 120 screened-positive case subjects and 120 screened-normal controls. African American (AA) women with positive 2nd trimester trisomy 21 screens (n=95) had a statistically significant higher risk for intrauterine growth retardation (p=0.01) and low birth weight (p=0.019). AA women who experienced adverse pregnancy outcome, in particular low birth weight, had a higher inhibin-A level as compared to controls. However, aneuploidy risk estimates and marker patterns from 2nd trimester screens were not associated with increased risk for adverse pregnancy outcome. These findings provide empirical evidence for guiding pregnancy management plans for these patients. 2009-10-13 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814 http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	African Americans Biomedical Research Genetics Health Care Minority and Ethnic Groups Obstetrics prental screeening test quad screens first trimester screens second trimester screens first check pregnancy complications adverse pregnancy outcomes obstetric complications African American pregnancy intrauterine growth retardation
spellingShingle	African Americans Biomedical Research Genetics Health Care Minority and Ethnic Groups Obstetrics prental screeening test quad screens first trimester screens second trimester screens first check pregnancy complications adverse pregnancy outcomes obstetric complications African American pregnancy intrauterine growth retardation Huang, Pinchia Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes
author	Huang, Pinchia
author_facet	Huang, Pinchia
author_sort	Huang, Pinchia
title	Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes
title_short	Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes
title_full	Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes
title_fullStr	Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes
title_full_unstemmed	Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes
title_sort	implications of false-positive trisomy 18 or 21 screening test results in predicting adverse pregnancy outcomes
publisher	Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate	2009
url	http://rave.ohiolink.edu/etdc/view?acc_num=case1247627814
work_keys_str_mv	AT huangpinchia implicationsoffalsepositivetrisomy18or21screeningtestresultsinpredictingadversepregnancyoutcomes
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Implications of False-Positive Trisomy 18 or 21 Screening Test Results in Predicting Adverse Pregnancy Outcomes

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