PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis
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Case Western Reserve University School of Graduate Studies / OhioLINK
2009
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-case12228954522021-08-03T05:32:55Z PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis D'Souza, Arun Biochemistry Computer Science Metabolomics pathway databases hypothesis generation interpretation closure tree The emerging area of Metabolomics provides new paradigms for diagnosis of diseases by rapidly and non-invasive providing specific bio-markers, useful for the diagnosis of early stages of diseases, and indicators of action sites of drugs. Emerging technologies are continuously increasing the number of metabolites that can be detected. Now there exists a need for computational tools to help clinical researchers to derive meaningful interpretations of metabolomics data. In this thesis we propose a metabolomic analysis workbench called PathCase<sup>MAW</sup> which provides (1) A web accessible metabolic pathway database which supports online browsing and querying, and is novel in that it includes location information for pathways and also models transport processes. (2) Tissue-aware visualization support for viewing process, pathways or groups of pathways from our database. (3) An online tool which allows users to upload their own observed/measured metabolite level changes and computationally identifies the mechanisms that produce those metabolite changes. 2009 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452 http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biochemistry Computer Science Metabolomics pathway databases hypothesis generation interpretation closure tree |
| spellingShingle |
Biochemistry Computer Science Metabolomics pathway databases hypothesis generation interpretation closure tree D'Souza, Arun PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis |
| author |
D'Souza, Arun |
| author_facet |
D'Souza, Arun |
| author_sort |
D'Souza, Arun |
| title |
PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis |
| title_short |
PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis |
| title_full |
PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis |
| title_fullStr |
PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis |
| title_full_unstemmed |
PathCase<sup>MAW</sup>: A Workbench for Metabolomic Analysis |
| title_sort |
pathcase<sup>maw</sup>: a workbench for metabolomic analysis |
| publisher |
Case Western Reserve University School of Graduate Studies / OhioLINK |
| publishDate |
2009 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=case1222895452 |
| work_keys_str_mv |
AT dsouzaarun pathcasesupmawsupaworkbenchformetabolomicanalysis |
| _version_ |
1719421571837198336 |