Positive Selection in Transcription Factor Genes Along the Human Lineage

Positive Selection in Transcription Factor Genes Along the Human Lineage

Bibliographic Details
Main Author: Nickel, Gabrielle Celeste
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2008
Subjects:
Bioinformatics
Genetics
Positive selection
transcription factors
maximum likelihood
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1220370670
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case12203706702021-08-03T05:32:55Z Positive Selection in Transcription Factor Genes Along the Human Lineage Nickel, Gabrielle Celeste Bioinformatics Genetics Positive selection transcription factors maximum likelihood The genetic changes that have occurred that led to the phenotypic divergence of modern Homo sapiens are unknown, as are the molecular mechanisms through which these changes transpired. A predominant theory in the field of human molecular evolution is that these changes happened because of the effects of adaptive protein evolution, also known as positive selection. This theory posits that amino acid changes have occurred along the human lineage that were beneficial to modern man and fixed in the population, thereby contributing to divergence. Transcription factors are proteins that regulate the expression of other genes, and they have a major role in embryogenesis and development. In this thesis, I have investigated transcription factor genes for human specific positive selection that contributed to the phenotypic divergence of humans and chimpanzees. Over the course of this work, I have developed a novel statistical approach for predicting positive selection that is particularly useful in closely related species, as I have shown that traditional methods lack power to detect selection along short branch lengths. I have also used genome wide expression arrays to test for differential activity and functional divergence of a human candidate transcription factor predicted to be positively selected. 2008-10-06 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1220370670 http://rave.ohiolink.edu/etdc/view?acc_num=case1220370670 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Bioinformatics
Genetics
Positive selection
transcription factors
maximum likelihood
spellingShingle Bioinformatics
Genetics
Positive selection
transcription factors
maximum likelihood
Nickel, Gabrielle Celeste
Positive Selection in Transcription Factor Genes Along the Human Lineage
author Nickel, Gabrielle Celeste
author_facet Nickel, Gabrielle Celeste
author_sort Nickel, Gabrielle Celeste
title Positive Selection in Transcription Factor Genes Along the Human Lineage
title_short Positive Selection in Transcription Factor Genes Along the Human Lineage
title_full Positive Selection in Transcription Factor Genes Along the Human Lineage
title_fullStr Positive Selection in Transcription Factor Genes Along the Human Lineage
title_full_unstemmed Positive Selection in Transcription Factor Genes Along the Human Lineage
title_sort positive selection in transcription factor genes along the human lineage
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=case1220370670
work_keys_str_mv AT nickelgabrielleceleste positiveselectionintranscriptionfactorgenesalongthehumanlineage
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