The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice
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Case Western Reserve University School of Graduate Studies / OhioLINK
2008
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-case12167445042021-08-03T05:32:55Z The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice Emancipator, Douglas Steven Biology Biomedical Research Immunology Helicobacter pylori Leptin receptor adaptive immune response <i>Helicobacter pylori</i> (<i>H. pylori</i>) infects the stomach of over half of the worldspopulation and often results in gastritis and ulcers. In addition, the World HealthOrganization has categorized <i>H. pylori</i> as a class I carcinogen. Still, little is known about how <i>H. pylori</i> induced gastritis arises and resolves. The adaptive immune response to <i>H. pylori</i> shapes proclivity to gastritis and clearance of infection. Recently, interaction of Leptin with its receptor has been recognized to modulate immune responses, and particularly reduces the T cells ability to incite inflammation. We hypothesized that the LepR modulates the adaptive immune response and thereby plays a significant role in the clearance of <i>H. pylori</i> from gastric mucosa. The data indicate that the LepR on CD4+ Tcells is required for clearance of <i>H. pylori</i> from infected SCID mice adoptivelytransferred with T cells. 2008-07-22 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504 http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
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English |
| sources |
NDLTD |
| topic |
Biology Biomedical Research Immunology Helicobacter pylori Leptin receptor adaptive immune response |
| spellingShingle |
Biology Biomedical Research Immunology Helicobacter pylori Leptin receptor adaptive immune response Emancipator, Douglas Steven The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice |
| author |
Emancipator, Douglas Steven |
| author_facet |
Emancipator, Douglas Steven |
| author_sort |
Emancipator, Douglas Steven |
| title |
The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice |
| title_short |
The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice |
| title_full |
The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice |
| title_fullStr |
The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice |
| title_full_unstemmed |
The Role of the Leptin Receptor on T Cells in Helicobacter Pylori Infection and Clearance in Mice |
| title_sort |
role of the leptin receptor on t cells in helicobacter pylori infection and clearance in mice |
| publisher |
Case Western Reserve University School of Graduate Studies / OhioLINK |
| publishDate |
2008 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=case1216744504 |
| work_keys_str_mv |
AT emancipatordouglassteven theroleoftheleptinreceptorontcellsinhelicobacterpyloriinfectionandclearanceinmice AT emancipatordouglassteven roleoftheleptinreceptorontcellsinhelicobacterpyloriinfectionandclearanceinmice |
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1719421557802008576 |