Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques

Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques

Bibliographic Details
Main Author: Stone, Meredith Elise
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2008
Subjects:
Biomedical Research
Engineering
Radiology
MRI
medical imaging
parameter estimation
blood vessels
cryo-imaging
T1
T2
proton density
image processing
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1212763005
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case12127630052021-08-03T05:32:35Z Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques Stone, Meredith Elise Biomedical Research Engineering Radiology MRI medical imaging parameter estimation blood vessels cryo-imaging T1 T2 proton density image processing Atherosclerotic vulnerable plaque imaging is an important clinical goal. Cryo-imaging can validate vessel tissue classification. A validation study showed overall sensitivity of 89% using naïve raters. However, cryo-imaging cannot be clinically translated. Instead, MRI microcoil imaging shows promise. An important component of MR tissue identification is parameter estimation of T1, T2, and proton density. A new parameter estimation method based on Maximum Likelihood Estimation accounting for Rician noise bias with Markov Random Field spatial regularization was developed. A flat image test case shows decreased noise levels comparable to neighborhood averaging. For the lowest signal-to-noise ratio test case, neighborhood averaging decreased the standard deviation of the error to 34% of the single-pixel techniques, while the new method decreased it 37-43%. Tests using simulated phantom image also show well-preserved edges, which is not possible with neighborhood averaging. Finally, the algorithm was tested on brain data to fit T2*, showing visually positive results. 2008-06-24 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1212763005 http://rave.ohiolink.edu/etdc/view?acc_num=case1212763005 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomedical Research
Engineering
Radiology
MRI
medical imaging
parameter estimation
blood vessels
cryo-imaging
T1
T2
proton density
image processing
spellingShingle Biomedical Research
Engineering
Radiology
MRI
medical imaging
parameter estimation
blood vessels
cryo-imaging
T1
T2
proton density
image processing
Stone, Meredith Elise
Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques
author Stone, Meredith Elise
author_facet Stone, Meredith Elise
author_sort Stone, Meredith Elise
title Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques
title_short Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques
title_full Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques
title_fullStr Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques
title_full_unstemmed Imaging of Blood Vessels: Parameter Estimation in MRI and Cryo-Imaging Techniques
title_sort imaging of blood vessels: parameter estimation in mri and cryo-imaging techniques
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=case1212763005
work_keys_str_mv AT stonemeredithelise imagingofbloodvesselsparameterestimationinmriandcryoimagingtechniques
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