SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY

SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY

Bibliographic Details
Main Author: Guo, Ming
Language:English
Published: Case Western Reserve University School of Graduate Studies / OhioLINK 2008
Subjects:
Chemistry
Pc
Si
CH2
CH3
3NH
HOSiPcOSi
CH2Cl2
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197
id ndltd-OhioLink-oai-etd.ohiolink.edu-case1206454197
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-case12064541972021-08-03T05:32:35Z SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY Guo, Ming Chemistry Pc Si CH2 CH3 3NH HOSiPcOSi CH2Cl2 <p>A series of Pc 4 related compounds consisting of OH-substituted derivatives, Pc 4 salts and Pc 4 OH-substituted derivative salts has been prepared. The salts have been synthesized by straightforward acid-base reactions. Solubility studies of the Pc 4, the OH-substituted derivatives, the Pc 4 salts and the OH-substituted derivative salts in representative organic solvents and in aqueous dispersant-containing solutions have been carried out. Different dosage forms of Pc 4 including a liquid salt, aqueous solutions, a mineral oil solution, gels, a cream, and water-swellable films have been formulated.</p><p> In addition, membrane penetration studies of the formulation of Pc 4 used in a completed Phase I clinical trial done at University Hospitals of Cleveland have been conducted. Polyurethane, cellulose, polyvinylidene fluoride, silicone, pig keratome, and human roof blister membranes have been used in the study.</p><p> In unrelated work, the known polymers, chrysotile-derived trimethylsiloxy scroll polymer, and chrysotile-derived vinyldimethylsiloxy scroll polymer have been made. Also, the new polymers chrysotile-derived trimethylsiloxy-3-cyanopropylmethylmethoxysiloxy scroll polymer and chrysotile-derived vinyldimethylsiloxy-3-cyanopropylmethylmethoxysiloxy scroll polymer, have been made by a novel pendent group-exchange reaction. Finally, partially platinum-filled scrolls have been prepared.</p> 2008-03-25 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197 http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Chemistry
Pc
Si
CH2
CH3
3NH
HOSiPcOSi
CH2Cl2
spellingShingle Chemistry
Pc
Si
CH2
CH3
3NH
HOSiPcOSi
CH2Cl2
Guo, Ming
SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
author Guo, Ming
author_facet Guo, Ming
author_sort Guo, Ming
title SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_short SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_full SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_fullStr SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_full_unstemmed SYNTHESIS AND CHARACTERIZATION OF SILICON PHTHALOCYANINES FOR PHOTODYNAMIC THERAPY
title_sort synthesis and characterization of silicon phthalocyanines for photodynamic therapy
publisher Case Western Reserve University School of Graduate Studies / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=case1206454197
work_keys_str_mv AT guoming synthesisandcharacterizationofsiliconphthalocyaninesforphotodynamictherapy
_version_ 1719421509283348480

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