Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
Case Western Reserve University School of Graduate Studies / OhioLINK
2007
|
| Subjects: | |
| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757 |
| id |
ndltd-OhioLink-oai-etd.ohiolink.edu-case1164830757 |
|---|---|
| record_format |
oai_dc |
| spelling |
ndltd-OhioLink-oai-etd.ohiolink.edu-case11648307572021-08-03T05:32:18Z Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism Miller, Katherine SNP DOM1 DOM2 LRP1 DISEASE BDNF allele With significant evidence supporting the role of lipid transport and/or lipid metabolism in late onset Alzheimer’s Disease (LOAD) susceptibility, we hypothesized that polymorphisms in genes coding for proteins involved in lipid pathways would make good candidates in an investigation of genetic risk and LOAD. We selected six genes associated both with LOAD and either directly or indirectly with lipid pathways to test in three case-control populations: Brain-derived Neurotrophic Factor (BDNF), Transthyretin (TTR), Tumor Necrosis Factor alpha (TNFa), Low-density Lipoprotein Receptor-related Protein (LRP1), Apolipoprotein L-3 (APOL3), and Sterol O-acyltransferase 1 (SOAT1). As an additional, exploratory analysis, we tested the hypothesis that dietary intake of lipids may modify the effect of these genes. Our results demonstrate a potentially significant role of LRP1 in protection against LOAD in the younger LOAD case-control population. In the elderly LOAD case-control population, we observed an association of borderline significance for TNFa, APOL3, and BDNF. Additional results of interest include observed but statistically non-significant effect modification of TTR by dietary fish intake. 2007-01-17 English text Case Western Reserve University School of Graduate Studies / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757 http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
SNP DOM1 DOM2 LRP1 DISEASE BDNF allele |
| spellingShingle |
SNP DOM1 DOM2 LRP1 DISEASE BDNF allele Miller, Katherine Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism |
| author |
Miller, Katherine |
| author_facet |
Miller, Katherine |
| author_sort |
Miller, Katherine |
| title |
Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism |
| title_short |
Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism |
| title_full |
Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism |
| title_fullStr |
Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism |
| title_full_unstemmed |
Genetic Susceptibility in Alzheimer’s Disease and the Role of Lipid Metabolism |
| title_sort |
genetic susceptibility in alzheimer’s disease and the role of lipid metabolism |
| publisher |
Case Western Reserve University School of Graduate Studies / OhioLINK |
| publishDate |
2007 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=case1164830757 |
| work_keys_str_mv |
AT millerkatherine geneticsusceptibilityinalzheimersdiseaseandtheroleoflipidmetabolism |
| _version_ |
1719421434055360512 |