Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection
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Bowling Green State University / OhioLINK
1979
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1566463066610384 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-bgsu15664630666103842021-08-03T07:12:54Z Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection Hashmi, A. Waheed Biology Guinea-pigs and jirds were used as laboratory models in order to assess comparatively the pathogenicity and immunogenicity of Parascaris equorum infection. Day to day hematological changes in both species were monitored and analysed statistically. A significant decrease in total erythrocyte count and concomitant decline in packed cell volume and hemoglobin values were found in jirds as compared to guinea-pigs. Generally, there was a significant elevation in total leukocyte count in both animals during the course of infection. But in the initial phase of infection in guinea-pigs a noticeable decline in total leukocyte population was accompanied by a significant shift in differential leukocyte count, characterized by increased neutrophilia. By contrast, in jirds an elevation in total leukocyte population was accompanied by a similar trend in the lymphoctye count. The level of neutrophils rose significantly through the course of infection in both hosts, but their build up was delayed considerably in jirds. In both animals a rise in lymphocyte population was observed in the final phase of infection. A gradual increase in eosinophilia with peaks from 10 through 14 DOI (day of infection) were observed in both animals. Monocytes showed an increase in the middle of the infection, and there was significant rise in basophils towards the end of the infection. Again, both these trends were more marked in guinea-pigs. Extensive tissue damage and hemorrhage were observed in lesions of the liver and lungs of jirds. This was accompanied by inadequate cellular response, which largely comprised of mononuclear cells. Massive cellular response was observed in the lesions in guinea-pigs. Among other infiltrates, polymorphonuclear cells were abundant, especially aggregates of eosinophils, which were indicative of an immediate type hypersensitive response in guinea-pigs. The larval recovery rate as well as the size range was greater for jirds. Consolidated evidence suggests a better host-parasite compatibility between guinea-pig and Parascaris eguorum due to a more effective cellular response by the host to the immunogenic stimulus of the parasite. 1979 English text Bowling Green State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1566463066610384 http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1566463066610384 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biology |
| spellingShingle |
Biology Hashmi, A. Waheed Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection |
| author |
Hashmi, A. Waheed |
| author_facet |
Hashmi, A. Waheed |
| author_sort |
Hashmi, A. Waheed |
| title |
Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection |
| title_short |
Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection |
| title_full |
Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection |
| title_fullStr |
Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection |
| title_full_unstemmed |
Cellular Reactions in Guinea-Pigs and Jirds during Parascaris Equorum Infection |
| title_sort |
cellular reactions in guinea-pigs and jirds during parascaris equorum infection |
| publisher |
Bowling Green State University / OhioLINK |
| publishDate |
1979 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1566463066610384 |
| work_keys_str_mv |
AT hashmiawaheed cellularreactionsinguineapigsandjirdsduringparascarisequoruminfection |
| _version_ |
1719456170966515712 |