The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus
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Bowling Green State University / OhioLINK
1971
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1554464085301051 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-bgsu15544640853010512021-08-03T07:10:08Z The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus Fireman, Barry I. Biology The present investigation dealt with the delicate association of the microfilariae of Dipetalonema vi.tea in their host, the gerbil, Meriones unguiculatus. The intermediate vector utilized was Ornithodoros tartakovskyi. The adult female worm deposited microfilariae into the host tissues. These microfilariae migrated to the circulation. The microfilariae lived for at least nine months. The number of microfilariae in the blood showed a cyclic fluctuation of between 32 and 48 hours from peak to peak. Through isotopic labeling and histologic studies it was determined that microfilariae were virtually non-existent in the tissues when dense in the blood, but when at minimal levels in the blood, were dispersed in cardiac and lung tissue. As the microfilariae increased in number in the circulation they were accompanied by antibody which was produced in response to non-somatic antigen (NSA) defined as secretory (enzymatic) and excretory (waste) metabolites produced by the microfilariae. Antibody was also produced in response to somatic antigen (SA). The titer of anti-NSA in the blood of gerbils experiencing high or low levels of worms in their circulation was determined by passive haemagglutination tests. The anti-NSA and anti-SA was shown by indirect fluorescent antibody techniques to be specific for both somatic and non-somatic microfilarial antigens. A serum toxicity test indicated that these antibodies could inactivate and kill microfilariae. The fluctuation of the microfilariae appeared to be influenced by the anti-NSA. The microfilariae entered the circulation when anti-NSA titers were low and left the circulation as the anti-NSA increased. The anti-NSA was determined to be immunoglobulin M (IgM). The migration of microfilariae into the circulation was inhibited when serum from gerbils with high numbers of microfilariae in their circulation was transferred intravenously into a gerbil with few microfilariae in its circulation. The inhibition was believed to be owing to an increase in the concentration of anti-NSA. Inversely, microfilarial levels increased sharply when serum from gerbils with low numbers of microfilariae in their circulation was transferred to a gerbil with a high number of microfilariae in its circulation. The increase was perhaps related to an effective dilution of anti-NSA. Microfilariae may have migrated into host tissues to avoid toxic levels of anti-NSA in the blood. It is hypothesized that microfilariae remained in the tissues until the critical level of serum anti-NSA decreased to the point where microfilarial survival in the blood was possible. 1971 English text Bowling Green State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1554464085301051 http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1554464085301051 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biology |
| spellingShingle |
Biology Fireman, Barry I. The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus |
| author |
Fireman, Barry I. |
| author_facet |
Fireman, Barry I. |
| author_sort |
Fireman, Barry I. |
| title |
The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus |
| title_short |
The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus |
| title_full |
The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus |
| title_fullStr |
The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus |
| title_full_unstemmed |
The Cyclic Behavior of the Microfilariae of Dipetalonema Vitea in its Host, Meriones Unguiculatus |
| title_sort |
cyclic behavior of the microfilariae of dipetalonema vitea in its host, meriones unguiculatus |
| publisher |
Bowling Green State University / OhioLINK |
| publishDate |
1971 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1554464085301051 |
| work_keys_str_mv |
AT firemanbarryi thecyclicbehaviorofthemicrofilariaeofdipetalonemaviteainitshostmerionesunguiculatus AT firemanbarryi cyclicbehaviorofthemicrofilariaeofdipetalonemaviteainitshostmerionesunguiculatus |
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