SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS

Bibliographic Details
Main Author:	Freedman, Abegel
Language:	English
Published:	University of Akron / OhioLINK 2020
Subjects:	Polymer Chemistry
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-akron16182356082616882021-08-03T07:17:09Z SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS Freedman, Abegel Polymer Chemistry Poly(ethylene glycol) (PEG) is a ubiquitous polymer in the biomaterials and drug delivery fields. PEG is thought to be nonimmunogenic and prolongs the half-life of circulating drug delivery vehicles. Most applications utilize methyl ether PEG (mPEG) with a linear architecture. The first part of this dissertation involves the synthesis of linear and cyclic (m)PEG based benzyl (meth)acrylate monomers for future lower critical solution temperature (LCST) studies. This will give the biomaterials field valuable insights into how the architecture of PEG affects the thermoresponsive properties of PEG containing polymers. The drug delivery field also primarily uses linear mPEG to evade protein adsorption. However, recent reports found that PEGylated drug delivery vehicles elicit an immune response upon multiple doses. Thus, the drug delivery field can benefit from a technique that directly detects protein adsorption onto PEGylated drug delivery vehicles at low concentrations. The second part of this dissertation focuses on utilizing fluorescence cross-correlation spectroscopy (FCCS) to detect protein adsorption onto micelles with varying PEG architectures. mPEG-polycaprolactone (PCL) was used to form micelles with a linear architecture and PCL-PEG-PCL was used to form micelles with a “cyclic” architecture. FCCS demonstrated that more bovine serum albumin (BSA) adsorbed onto PCL-PEG-PCL micelles than the mPEG-PCL micelles. It also revealed different adsorption trends, as mPEG-PCL had delayed interactions with BSA, after 12 hours, while PCL-PEG-PCL had immediate interactions with a plateau after 12 hours. 2020 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688 http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Polymer Chemistry
spellingShingle	Polymer Chemistry Freedman, Abegel SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS
author	Freedman, Abegel
author_facet	Freedman, Abegel
author_sort	Freedman, Abegel
title	SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS
title_short	SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS
title_full	SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS
title_fullStr	SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS
title_full_unstemmed	SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS
title_sort	synthesis, assembly, and protein adsorption studies on linear and cyclic peg containing monomers and polymers
publisher	University of Akron / OhioLINK
publishDate	2020
url	http://rave.ohiolink.edu/etdc/view?acc_num=akron1618235608261688
work_keys_str_mv	AT freedmanabegel synthesisassemblyandproteinadsorptionstudiesonlinearandcyclicpegcontainingmonomersandpolymers
_version_	1719458238444863488

SYNTHESIS, ASSEMBLY, AND PROTEIN ADSORPTION STUDIES ON LINEAR AND CYCLIC PEG CONTAINING MONOMERS AND POLYMERS

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