COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS

Bibliographic Details
Main Author:	Cruz, Megan A.
Language:	English
Published:	University of Akron / OhioLINK 2020
Subjects:	Polymer Chemistry Biomedical Research
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=akron1607075278756378

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-akron16070752787563782021-08-03T07:16:31Z COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS Cruz, Megan A. Polymer Chemistry Biomedical Research Thermoresponsive or “smart” polymers, such as those exhibiting a LowerCritical Solution Temperature (LCST), have found broad utility in a number ofdifferent biomedical applications. Particularly useful are thermoresponsive polymersthat form coacervates above their LCST. Coacervation is a liquid-liquid phaseseparation which results in polymer-rich mesoglobules suspended in an aqueoussolution, capable of enriching other species in the medium. Thermoresponsivepolyester (TR-PE) coacervates are used in this work to encapsulate proteins toaddress an outstanding medical need for a vehicle which can protect and delivertherapeutic proteins over a prolonged period. In this work, a diverse library ofTR-PEs was developed. An almost limitless number of biomolecules could potentiallybe enveloped within these carriers based on selection of pendant group andincorporation of linker groups by copolymerization. Furthermore, these excellentbiomaterials are hydrolytically degradable, nontoxic, and non-damaging to nativeprotein concentration. Efficient encapsulation of model proteins by ionic interactionsand covalent conjugation illustrate a first step towards translation of thisplatform into the clinic. TR-PEs designed to combat chronic wounds were capableof sustained delivery of crucial growth factors. These features make TR-PEsexcellent biomaterials for protein delivery applications. 2020 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1607075278756378 http://rave.ohiolink.edu/etdc/view?acc_num=akron1607075278756378 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Polymer Chemistry Biomedical Research
spellingShingle	Polymer Chemistry Biomedical Research Cruz, Megan A. COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS
author	Cruz, Megan A.
author_facet	Cruz, Megan A.
author_sort	Cruz, Megan A.
title	COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS
title_short	COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS
title_full	COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS
title_fullStr	COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS
title_full_unstemmed	COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS
title_sort	coacervate-forming thermoresponsive polyesters asprotein delivery platforms
publisher	University of Akron / OhioLINK
publishDate	2020
url	http://rave.ohiolink.edu/etdc/view?acc_num=akron1607075278756378
work_keys_str_mv	AT cruzmegana coacervateformingthermoresponsivepolyestersasproteindeliveryplatforms
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COACERVATE-FORMING THERMORESPONSIVE POLYESTERS ASPROTEIN DELIVERY PLATFORMS

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