Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications
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University of Akron / OhioLINK
2019
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=akron1574679178325714 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron15746791783257142021-08-03T07:13:15Z Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications Bishop, Paul D. Biomedical Engineering Biomedical Research Vascular atherosclerosis superficial femoral artery intravascular ultrasound 3D three dimensional printing reconstruction Peripheral arterial disease (PAD) is the result of an obstruction of arteries that limits blood flow to the extremities which impacts an estimated 8.5 million Americans with nearly 40% showing no symptoms of the disease. Of those with PAD, the femoral and popliteal arteries are affected in as many as 90% of people. Severe PAD can lead to ischemic ulceration, gangrene, and potentially major amputation of the affected limbs if left untreated. Arterial geometry is a known factor of treatment success for minimally invasive devices such as stents. Much of the geometry data used for describing the lower extremities has been leveraged from data presented in coronary literature although coronary vessels are known to differ from peripheral arteries. Recently, a 2019 FDA warning for SFA paclitaxel SFA stents noting mortality concerns has triggered a call by vascular researchers to for fundamental SFA geometry and plaque morphology characterization. This characterization is needed to better understand the environment SFA stents experience following implant. The main objective of this effort has identified and summarized one of the largest virtual histology IVUS datasets known to exist of the SFA. IVUS is one of the highest resolution imaging modalities clinically used to visualize arteries. Geometry and plaque morphology are summarized for a 79-subject cohort. Similarly, associations with demographic and medical comorbidities are presented. The second objective of this research developed 3D printing methodology to introduce patient specific mechanical properties to a geometrically accurate SFA model. These findings also allow the model to serve as an ultrasound phantom for medical imaging. The third objective of this effort has developed a software algorithm that allows the IVUS imaging of an SFA stent to be 3D reconstructed. This software allows for current and future stents to be imaged without ionizing radiation. These three objectives provide a solid foundation for SFA stent researchers to better evaluate device design in the SFA native environment, create better benchtop models from 3D printing, and to evaluate implanted device geometry. These findings are also anticipated to be leveraged for patient specific medicine and predictive outcome algorithms for arterial devices. 2019 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1574679178325714 http://rave.ohiolink.edu/etdc/view?acc_num=akron1574679178325714 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomedical Engineering Biomedical Research Vascular atherosclerosis superficial femoral artery intravascular ultrasound 3D three dimensional printing reconstruction |
| spellingShingle |
Biomedical Engineering Biomedical Research Vascular atherosclerosis superficial femoral artery intravascular ultrasound 3D three dimensional printing reconstruction Bishop, Paul D. Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications |
| author |
Bishop, Paul D. |
| author_facet |
Bishop, Paul D. |
| author_sort |
Bishop, Paul D. |
| title |
Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications |
| title_short |
Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications |
| title_full |
Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications |
| title_fullStr |
Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications |
| title_full_unstemmed |
Geometry and Plaque Morphology of the Superficial Femoral Artery with Clinical Implications |
| title_sort |
geometry and plaque morphology of the superficial femoral artery with clinical implications |
| publisher |
University of Akron / OhioLINK |
| publishDate |
2019 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1574679178325714 |
| work_keys_str_mv |
AT bishoppauld geometryandplaquemorphologyofthesuperficialfemoralarterywithclinicalimplications |
| _version_ |
1719456455566819328 |