Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects
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University of Akron / OhioLINK
2018
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron15302220317257092021-08-03T07:07:10Z Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects Robishaw, Nikki K. Biomedical Research Chemistry Medicine Nanotechnology Pharmaceuticals Polymers N-heterocyclic carbenes silver nanoparticles PLGA-PEG drug delivery anti-tumor lung cancer antimicrobial targeted targeting folic acid cRGD Presently in the United States, cancer is the second leading cause of death for both men and women, with lung cancer attributing to approximately 28% of all cancer related deaths. Lung cancer can further be separated into two categories: small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). Treatment of NSCLC will depend on the stage of the cancer and can include surgery, chemotherapy, and/or radiation therapy. Chemotherapy often involves a mixture of organic-based and heavy metal-based drugs. The downside of these drugs are that they usually have a narrow therapeutic index and can have detrimental side effects. Due to these downsides, there is a continuous need to develop new anti-tumor agents that have a wider therapeutic index to reduce devastating side effects on the patient while having the desired effect on the tumor cell. Recently, the Youngs group had developed silver N-heterocyclic carbene complexes that show in vitro anticancer properties against NSCLC cell lines, however, solubility of the drugs is an issue.This dissertation describes encapsulating these complexes into biodegradable nanoparticles, in vitro and in vivo testing of the nanoparticles as well as various compounds against a panel of cancerous cell lines. Chapter I goes into the background of medicinal N-heterocyclic carbene complexes and the background of various nanoparticles used for drug delivery as well as the fabrication of the nanoparticle. Chapter II discusses the synthesis of the biodegradable nanoparticles made from poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) nanoparticles, encapsulation of the complexes, and use of various targeting moieties decorating the nanoparticle surface. In vitro testing for antimicrobial and anticancer properties are also reported. Chapter III aims to optimize silver N-heterocyclic carbene complexes into PLGA-PEG nanoparticles and studies the antimicrobial activities of these systems. Chapter IV shows the in vitro anticancer properties of multiple imidazolium cations and their silver counterparts. These complexes were tested on multiple NSCLC cell lines and their anticancer properties are shown. Chapter V focuses on the in vivo toxicity of some carbene complexes as well as complexes that were encapsulated into nanoparticles. 2018-09-14 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1530222031725709 http://rave.ohiolink.edu/etdc/view?acc_num=akron1530222031725709 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomedical Research Chemistry Medicine Nanotechnology Pharmaceuticals Polymers N-heterocyclic carbenes silver nanoparticles PLGA-PEG drug delivery anti-tumor lung cancer antimicrobial targeted targeting folic acid cRGD |
| spellingShingle |
Biomedical Research Chemistry Medicine Nanotechnology Pharmaceuticals Polymers N-heterocyclic carbenes silver nanoparticles PLGA-PEG drug delivery anti-tumor lung cancer antimicrobial targeted targeting folic acid cRGD Robishaw, Nikki K. Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects |
| author |
Robishaw, Nikki K. |
| author_facet |
Robishaw, Nikki K. |
| author_sort |
Robishaw, Nikki K. |
| title |
Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects |
| title_short |
Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects |
| title_full |
Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects |
| title_fullStr |
Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects |
| title_full_unstemmed |
Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects |
| title_sort |
encapsulating n-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects |
| publisher |
University of Akron / OhioLINK |
| publishDate |
2018 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1530222031725709 |
| work_keys_str_mv |
AT robishawnikkik encapsulatingnheterocycliccarbenecomplexesintobiodegradablenanoparticlesandtheantimicrobialandantitumoreffects |
| _version_ |
1719453842039373824 |