Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration
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University of Akron / OhioLINK
2016
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=akron1478000902817738 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron14780009028177382021-12-17T05:24:08Z Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration Wade, Mary E. Biomechanics Biomedical Engineering Biomedical Research Biology Cellular Biology Chemistry Polymer Chemistry Polymers elastomer electrospinning melt spinning 3D printing sterilization sewing extracellular matrix biomimicry tissue regeneration inflammation biomaterial Discoveries of new synthetic polymeric materials have become increasingly important in the field of biomedicine. Recent advancements in bio-functionalization strategies have led to innovation of biomimetic materials that can enhance tissue regeneration. Poly(ester urea)s are one unique set of materials comprised of amino acids and diols that are able to achieve tunable mechanical and degradation properties for a variety of tissue engineering applications. These materials can be functionalized with peptides utilizing an assortment of strategies in order to enhance cellular and tissue interactions. One alternative functionalization strategy under current investigation is combining decellularized extracellular matrix with poly(ester urea)s using engineering approaches such as electrospinning, melt-spinning, and 3D-printing. Our research into these techniques has provided interesting insights into the effects of processing on nanostructured scaffolds, and how molecular and scaffold structure can be tailored to overcome processing obstacles.We have also recently discovered a new series of elastomeric materials inspired by the chemical structure of rubber. These new polymers also exhibit tunable mechanical and degradation properties. We have tested these elastomers in vitro and in vivo and observed excellent cellular and tissue responses. Elastomers containing a degradable monomer in every copolymer repeat unit were capable of degrading within a period of 4 months in vivo while allowing for significant tissue infiltration and matrix regeneration. These two examples support the use of biomimicry for the design of novel materials, from molecular synthetic strategies to macromolecular scaffold design, and similar approaches will play a critical role in furthering the development of biomaterials for tissue regeneration. 2016 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1478000902817738 http://rave.ohiolink.edu/etdc/view?acc_num=akron1478000902817738 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomechanics Biomedical Engineering Biomedical Research Biology Cellular Biology Chemistry Polymer Chemistry Polymers elastomer electrospinning melt spinning 3D printing sterilization sewing extracellular matrix biomimicry tissue regeneration inflammation biomaterial |
| spellingShingle |
Biomechanics Biomedical Engineering Biomedical Research Biology Cellular Biology Chemistry Polymer Chemistry Polymers elastomer electrospinning melt spinning 3D printing sterilization sewing extracellular matrix biomimicry tissue regeneration inflammation biomaterial Wade, Mary E. Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration |
| author |
Wade, Mary E. |
| author_facet |
Wade, Mary E. |
| author_sort |
Wade, Mary E. |
| title |
Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration |
| title_short |
Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration |
| title_full |
Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration |
| title_fullStr |
Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration |
| title_full_unstemmed |
Engineering of Elastomeric Biomaterials and Biomimicry of Extracellular Matrix for Soft Tissue Regeneration |
| title_sort |
engineering of elastomeric biomaterials and biomimicry of extracellular matrix for soft tissue regeneration |
| publisher |
University of Akron / OhioLINK |
| publishDate |
2016 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1478000902817738 |
| work_keys_str_mv |
AT wademarye engineeringofelastomericbiomaterialsandbiomimicryofextracellularmatrixforsofttissueregeneration |
| _version_ |
1723964495869509632 |