The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio
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University of Akron / OhioLINK
2015
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron14384566142021-08-03T06:32:33Z The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio Ickes, Jessica R. Biology Developmental Biology Physiology methamphetamine cardiovascular cardiac development zebrafish aggression The stimulant effects of methamphetamine are known to affect cardiovascular function and behavior in rats and adult humans, but little is known about cardiovascular development in the presence of methamphetamine. The purpose of this study was to determine if methamphetamine exposure (acute and chronic) affects the survivability and cardiovascular development of zebrafish (Danio rerio) embryos. Zebrafish embryos were either injected with a single dose of methamphetamine (acute exposure) or soaked in a methamphetamine solution for 24 hours (chronic exposure). Survival, morphological development, and cardiovascular development were recorded at 48 hours post-fertilization. Embryonic methamphetamine exposure resulted in increased eye size, cardiac output, and red blood cell velocity and a decreased yolk size. Behavior was also assessed in juvenile zebrafish to determine methamphetamine’s role in aggression and avoidance behaviors. Four month old zebrafish were injected with either methamphetamine or a saline control and subjected to mirror image stimulation to quantify aggression. No differences were found in the amount of aggression or avoidance between methamphetamine-exposed fish and control fish. Methamphetamine exposure during development causes select cardiovascular and morphological alterations, while exposure to juvenile fish has no effect on certain behaviors such as aggression and avoidance. 2015-09-14 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614 http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biology Developmental Biology Physiology methamphetamine cardiovascular cardiac development zebrafish aggression |
| spellingShingle |
Biology Developmental Biology Physiology methamphetamine cardiovascular cardiac development zebrafish aggression Ickes, Jessica R. The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio |
| author |
Ickes, Jessica R. |
| author_facet |
Ickes, Jessica R. |
| author_sort |
Ickes, Jessica R. |
| title |
The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio |
| title_short |
The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio |
| title_full |
The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio |
| title_fullStr |
The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio |
| title_full_unstemmed |
The Effects of Acute and Chronic Methamphetamine Exposure on Cardiovascular Development, Developmental Rate, and Aggression in Danio rerio |
| title_sort |
effects of acute and chronic methamphetamine exposure on cardiovascular development, developmental rate, and aggression in danio rerio |
| publisher |
University of Akron / OhioLINK |
| publishDate |
2015 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1438456614 |
| work_keys_str_mv |
AT ickesjessicar theeffectsofacuteandchronicmethamphetamineexposureoncardiovasculardevelopmentdevelopmentalrateandaggressionindaniorerio AT ickesjessicar effectsofacuteandchronicmethamphetamineexposureoncardiovasculardevelopmentdevelopmentalrateandaggressionindaniorerio |
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