Development of New Treatment Modalities for Kidney/Ureter Stones
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University of Akron / OhioLINK
2015
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=akron1435153573 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron14351535732021-08-03T06:31:40Z Development of New Treatment Modalities for Kidney/Ureter Stones Najafi, Zahra Biomedical Engineering Biomechanics Design Computational Fluid Dynamic ureter peristaltic mathematical model ureteroscopy extraction force measurements design of a new smart kidney basket The number of people suffering from urolithiasis (formation of kidney stones) has increased over the past few decades. Ureteroscopic stone extraction devices are effective and ubiquitous tools in the management of urolithiasis. These devices, however, have the potential to cause injury to the ureter. Avulsion and perforation of the ureter as a result of excessive forces on the extraction device are the most serious complications of this treatment. Moreover, effective management of kidney stones depends on their size, location, and composition. In this dissertation, different treatment modalities for kidney stone disease are discussed. In the first part of this dissertation, analysis of the peristaltic movement, which drives the urine from the kidneys to the bladder through the ureter, is presented. More specifically, different sizes and types of kidney stones are modeled inside the ureter and their effects on the urine flow and pressure on the ureter wall are studied. It is concluded that in addition to the stone size, different stone shapes result in different pressures on the ureter wall. In the second part of this dissertation, a kidney basket prototype with a force sensor has been developed. This device was built based on the measured injury forces during basketing, using two different setups, a benchtop model and an ex-vivo porcine ureter. The force sensor provides instantaneous visual force measurements imposed on the ureter wall during stone extraction, and thereby, aids in reducing the risk of complications by highlighting the safety and hazardous extraction forces. The tests were performed in conjunction with the Division of Urology, Southern Illinois University, School of Medicine, Springfield, IL. The results obtained from these tests were consistent with injury forces reported in the literature. The designed prototype, together with the stone analysis performed in this study could potentially lead to an improvement in the treatment of urolithiasis and enhance patient outcomes. 2015-09-10 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1435153573 http://rave.ohiolink.edu/etdc/view?acc_num=akron1435153573 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomedical Engineering Biomechanics Design Computational Fluid Dynamic ureter peristaltic mathematical model ureteroscopy extraction force measurements design of a new smart kidney basket |
| spellingShingle |
Biomedical Engineering Biomechanics Design Computational Fluid Dynamic ureter peristaltic mathematical model ureteroscopy extraction force measurements design of a new smart kidney basket Najafi, Zahra Development of New Treatment Modalities for Kidney/Ureter Stones |
| author |
Najafi, Zahra |
| author_facet |
Najafi, Zahra |
| author_sort |
Najafi, Zahra |
| title |
Development of New Treatment Modalities for Kidney/Ureter Stones |
| title_short |
Development of New Treatment Modalities for Kidney/Ureter Stones |
| title_full |
Development of New Treatment Modalities for Kidney/Ureter Stones |
| title_fullStr |
Development of New Treatment Modalities for Kidney/Ureter Stones |
| title_full_unstemmed |
Development of New Treatment Modalities for Kidney/Ureter Stones |
| title_sort |
development of new treatment modalities for kidney/ureter stones |
| publisher |
University of Akron / OhioLINK |
| publishDate |
2015 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1435153573 |
| work_keys_str_mv |
AT najafizahra developmentofnewtreatmentmodalitiesforkidneyureterstones |
| _version_ |
1719438267321942016 |