Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform
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University of Akron / OhioLINK
2015
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=akron1424234383 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron14242343832021-08-03T06:29:18Z Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform Sun, Shuangyi Polymers Photoresponsive polymers have unique properties and are increasingly studied for various biomaterial applications. This dissertation described a unique approach of incorporating the alkoxyphenacyl chromophore to prepare photodegradable polycarbonates, polyesters, and polyacrylates. The phenacyl group was previously used as a phototriggers for the release of phosphates, amino acids, peptides, and carboxylic acids. In the current research the alkoxyphenacyl chromophore was incorporated directly in the polymer backbone to make polycarbonates and polyesters. The polycarbonate and polyesters showed efficient chain scission upon irradiation at 300 nm UV light even in presence of oxygen. SEC, UV, 1H NMR, and MS were employed to analyze the photodegradation process and mechanism. A study of photodegradation in oxygen-free environment showed a faster degradation rate. Polycarbonate nanoparticles were loaded with Nile Red for a controlled chemical release study. The efficient polymer chain scission even in the presence of oxygen enabled facile fabrication of micropatterned surfaces which are potentially useful for creating biomedical implants. Amine group was introduced to the polymer as pendent group by polymerization with Boc-L-glutamic acid, which allowed conjugation of functional molecules such as rhodamine B and FITC via surface chemistry or solution chemistry. Subsequent surface patterning created fluorescent patterned surface. The polymers were open to further functionalization at the carbonyl group with hydrazide to create dual fluorescent patterns, where two patterns bearing green and red fluorescence overlaps with each other. Hydroxylamine conjugated RGD peptide was functionalized at the surface of the polymer coating, and selective photodegradation of the polymer coating through a mask created a spatial defined RGD peptide micropatterned surface. 2015-05-27 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1424234383 http://rave.ohiolink.edu/etdc/view?acc_num=akron1424234383 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Polymers |
| spellingShingle |
Polymers Sun, Shuangyi Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform |
| author |
Sun, Shuangyi |
| author_facet |
Sun, Shuangyi |
| author_sort |
Sun, Shuangyi |
| title |
Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform |
| title_short |
Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform |
| title_full |
Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform |
| title_fullStr |
Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform |
| title_full_unstemmed |
Alkoxyphenacyl Polymers: A Novel Photodegradable Polymer Platform |
| title_sort |
alkoxyphenacyl polymers: a novel photodegradable polymer platform |
| publisher |
University of Akron / OhioLINK |
| publishDate |
2015 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1424234383 |
| work_keys_str_mv |
AT sunshuangyi alkoxyphenacylpolymersanovelphotodegradablepolymerplatform |
| _version_ |
1719437527933255680 |