Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels

Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels

Bibliographic Details
Main Author: Lu, Xing
Language:English
Published: University of Akron / OhioLINK 2013
Subjects:
Materials Science
Polymers
Drug delivery
Hydrogel
Hydrophobical Modification
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-akron13866310602021-08-03T06:21:06Z Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels Lu, Xing Materials Science Polymers Drug delivery Hydrogel Hydrophobical Modification Copolymers of hydrophilic N,N-dimethylacrylamide (DMA) and hydrophobic 2-(N-ethylperfluorooctane sulfonamido) ethyl methacrylate (FOSM) was synthesized by free radical polymerization with FOSM quantitatively incorporated ranging in composition from 0% to 30% as demonstrated by 1H-NMR. These polymers can form hydrogels in an aqueous environment through hydrophobic association of the FOSM moieties which act as physical cross-links. Thermal properties, water content, drug uptake and release behavior was investigated. Tg and water content decreased with the increasing incorporation of FOSM. Cyclosporine A (CsA), an immunosuppressant agent, was selected as the model drug substance and loaded into the hydrogels. CsA showed higher affinity for the polymer phase and the preference increased with increasing FOSM content. A first-order release profile was observed for hydrogels presoaked in aqueous solution. Release exponent (n=0.5) suggested the drug release mechanism was Fickian. A pseudo zero-order release behavior was observed for hydrogels presoaked in DMSO/water mixture solution. Release exponent (n=0.7) implied an anomalous mechanism. A combined model was proposed assuming simultaneous Fickian diffusion from hydrophilic matrix and diffusion from FOSM nanodomains as nano drug reservoirs for kinetics and mechanism analysis. In both cases, drug transport rate attenuated with increasing hydrophobic modification suggesting drug release behavior can be tuned by FOSM content. Drug diffusion coefficients were obtained by model fitting based on early-time, Etters approximation and combined model assumption. The duration of CsA release within therapeutic window can be extended to 15 days from these hydrogels. These thermo-processible hydrogels have potential to be used as controlled ocular drug delivery devices. 2013 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060 http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Materials Science
Polymers
Drug delivery
Hydrogel
Hydrophobical Modification
spellingShingle Materials Science
Polymers
Drug delivery
Hydrogel
Hydrophobical Modification
Lu, Xing
Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels
author Lu, Xing
author_facet Lu, Xing
author_sort Lu, Xing
title Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels
title_short Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels
title_full Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels
title_fullStr Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels
title_full_unstemmed Controlled Release of Cyclosporine A from Hydrophobically-modified Hydrogels
title_sort controlled release of cyclosporine a from hydrophobically-modified hydrogels
publisher University of Akron / OhioLINK
publishDate 2013
url http://rave.ohiolink.edu/etdc/view?acc_num=akron1386631060
work_keys_str_mv AT luxing controlledreleaseofcyclosporineafromhydrophobicallymodifiedhydrogels
_version_ 1719434868943749120

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