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ndltd-OhioLink-oai-etd.ohiolink.edu-akron1321533696
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oai_dc
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron13215336962021-08-03T05:26:49Z 1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane Makal, Nergis <p>Dendritic, or highly branched, structures exist in nature in various dimensions in both biological and non-biological systems. These structures provide maximized surface areas; therefore, they provide a platform to optimize energy, nutrition, and information exchange. In the (macro)molecular regime, the size, shape, and functionality are important features of a dendrimer that can be precisely controlled,1,2 which ultimately affect their physical properties, such as solution conformation. A unique characteristic of dendritic architectures is their globular or "3-dimensional" shape that can be amplified by the use of shape-persistent building blocks.3 Thus, adamantane was chosen, as a building block, for the construction of 1 to 3 branched, dendritic frameworks. Adamantane is an ideal candidate due to its three, fused cyclohexane rings, which are all in strain-free, chair conformations that can generate a 3-D shape-persistent structure.4 The construction of adamantane building blocks and their incorporation into dendritic macromolecules will be discussed. </p><p>Adamantane functionalization was achieved at the bridgehead positions to generate the novel 1-amino-3,5,7-tris(methoxycarbonyl)adamantane monomer, which with the corresponding 1,3,5,7-adamantanetetracarboxylic acid will be used to construct the initial dendrimers. These materials will be compared to the well-known Newkome-type dendrimers that have been constructed with di-tert-butyl-4-amino-4-[2-(tert-butoxycarbonyl) ethyl] heptanedioate (Behera's amine).2 Notably, this building block has a similar shape yet does not possess shape-persistence.</p> 2011-12-09 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1321533696 http://rave.ohiolink.edu/etdc/view?acc_num=akron1321533696 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
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| collection |
NDLTD
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| language |
English
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| sources |
NDLTD
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| author |
Makal, Nergis
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| spellingShingle |
Makal, Nergis
1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane
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| author_facet |
Makal, Nergis
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| author_sort |
Makal, Nergis
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| title |
1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane
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| title_short |
1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane
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| title_full |
1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane
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| title_fullStr |
1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane
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| title_full_unstemmed |
1-Amino-3,5,7-Tris(Methoxycarbonyl)Adamantane
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| title_sort |
1-amino-3,5,7-tris(methoxycarbonyl)adamantane
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| publisher |
University of Akron / OhioLINK
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| publishDate |
2011
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| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1321533696
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| work_keys_str_mv |
AT makalnergis 1amino357trismethoxycarbonyladamantane
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| _version_ |
1719420198625214464
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