The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems
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University of Akron / OhioLINK
2010
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=akron1289840898 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-akron12898408982021-08-03T05:26:14Z The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems Peck, Jennifer L. Physiology Hypertension Sympathetic nervous system Restraint stress Renal interlobar Human cardiovascular diseases are often preceded by and exaggerated with perceived stress. This can affect a variety of physiological processes including blood pressure, sympathetic nervous system (SNS) activity, and vascular reactivity. To investigate these mechanisms, acute restraint stress was applied and systolic blood pressure (SBP), plasma and urinary catecholamines (CA), and responses of isolated renal interlobar arteries to the vasoconstrictor phenylephrine (PE) were assessed. The hypothesis was that acute restraint stress would increase endogenous SNS activity by increasing plasma norepinephrine (NE) and increase constriction of renal interlobar arteries, which would result in a more potentiated response in SHR males compared to WKY. Adult male SHR and WKY rats were subjected to four weeks of 1hr restraint stress (n=8, 3 days/wk) compared to control. Blood pressure was measured weekly via tail spyhgmanometry, and CAs were assayed by HPLC. Small, resistance- sized renal interlobar artery constriction in response to PE was determined using a pressurized arteriograph system. SHR and WKY restraint stressed animals exhibited increased plasma and urinary norepinephrine (NE) and epinephrine (EPI). Constrictor responses to PE in SHR and WKY stressed animals were decreased when compared to control animals. In conclusion, acute restraint stress does increase SNS activity with increased plasma NE, and renal artery constriction. Vasoconstrictor responses of isolated renal arteries appears to be increased, possibly as a result of higher density of α1- and α2-adrenoceptors leading to increase use and binding of NE which may have led to the increased SBP seen in these animals. 2010-12-13 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1289840898 http://rave.ohiolink.edu/etdc/view?acc_num=akron1289840898 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Physiology Hypertension Sympathetic nervous system Restraint stress Renal interlobar |
| spellingShingle |
Physiology Hypertension Sympathetic nervous system Restraint stress Renal interlobar Peck, Jennifer L. The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems |
| author |
Peck, Jennifer L. |
| author_facet |
Peck, Jennifer L. |
| author_sort |
Peck, Jennifer L. |
| title |
The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems |
| title_short |
The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems |
| title_full |
The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems |
| title_fullStr |
The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems |
| title_full_unstemmed |
The Effects of Acute Restraint Stress on Renal Vasculature Reactivity and the Sympathetic Nervous Systems |
| title_sort |
effects of acute restraint stress on renal vasculature reactivity and the sympathetic nervous systems |
| publisher |
University of Akron / OhioLINK |
| publishDate |
2010 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=akron1289840898 |
| work_keys_str_mv |
AT peckjenniferl theeffectsofacuterestraintstressonrenalvasculaturereactivityandthesympatheticnervoussystems AT peckjenniferl effectsofacuterestraintstressonrenalvasculaturereactivityandthesympatheticnervoussystems |
| _version_ |
1719420116694728704 |