Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms

Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms

Bibliographic Details
Main Author: Adya, Vandana
Language:English
Published: University of Akron / OhioLINK 2008
Subjects:
Biomedical Research
optical imaging
liquid phantoms
backscattered signal
DQE
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-akron12252046202021-08-03T05:25:36Z Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms Adya, Vandana Biomedical Research optical imaging liquid phantoms backscattered signal DQE The main purpose of this study is to explore the potential of optically active molecules in conjunction with single pixel detectors and polarimetric techniques for early detection of tissue pathologies. Optical polarimetry can provide invaluable biological information based on molecular composition of the medium, structure, geometry, and metabolism. The preclinical phantom used was a rectangular plexiglass container and the experiments were carried out under backscattering detection geometry. A NIRVANA (Newfocus Inc., Model 2007, Santa Clara, CA, USA) auto balance detector was employed throughout the study. Initial readings were taken with water, and then aqueous solution of optically active molecules was added into it. The readings were obtained for the two states of polarization of light, parallel and perpendicular polarization. The signal-to-noise ratio and detective quantum efficiency (DQE) were calculated. The outcome of this study indicated an increase of the backscattered detected signal, signal-to-noise ratio, and the DQE of the imaging system, with increase in the concentration of optically active contrast agents. The results obtained were validated by performing linear regression analysis and paired t-test. The statistical analysis indicated increase in backscattered detected signal, signal to noise ratio, DQE and significant difference between the two states of polarization. This increase in the backscattered signal due to difference in the refractive index between the background and the object, leads to an increased contrast image that would assist in the early detection of tumor, other tissue pathologies, and biological structures. 2008 English text University of Akron / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620 http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomedical Research
optical imaging
liquid phantoms
backscattered signal
DQE
spellingShingle Biomedical Research
optical imaging
liquid phantoms
backscattered signal
DQE
Adya, Vandana
Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms
author Adya, Vandana
author_facet Adya, Vandana
author_sort Adya, Vandana
title Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms
title_short Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms
title_full Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms
title_fullStr Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms
title_full_unstemmed Detection of Signal Parameters and Backscattering Polarimetric Imaging Signatures using Molecular Optical Contrast Agents and Preclinical Liquid Phantoms
title_sort detection of signal parameters and backscattering polarimetric imaging signatures using molecular optical contrast agents and preclinical liquid phantoms
publisher University of Akron / OhioLINK
publishDate 2008
url http://rave.ohiolink.edu/etdc/view?acc_num=akron1225204620
work_keys_str_mv AT adyavandana detectionofsignalparametersandbackscatteringpolarimetricimagingsignaturesusingmolecularopticalcontrastagentsandpreclinicalliquidphantoms
_version_ 1719419967660621824

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