Regulation of mouse ribonucleotide reductase by allosteric effector-substrate interplay and hypoxia

Regulation of mouse ribonucleotide reductase by allosteric effector-substrate interplay and hypoxia

In order to maintain genetic stability in eukaryotes, tight regulation of the relative sizes of deoxyribonucleoside triphosphate (dNTP) levels inside the cell is essential for optimal fidelity of DNA replication. Ribonucleotide reductase (RNR) is the enzyme responsible for proportional production of...

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Bibliographic Details
Main Author: Chimploy, Korakod
Other Authors: Mathews, Christopher K.
Language:en_US
Published: 2012
Subjects:
DNA replication > Regulation
Mice > Genetics
Allosteric regulation
Ribonucleoside diphoshate reductase > Regulation
Online Access:http://hdl.handle.net/1957/31161

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