Regulation of mouse ribonucleotide reductase by allosteric effector-substrate interplay and hypoxia
In order to maintain genetic stability in eukaryotes, tight regulation of the relative sizes of deoxyribonucleoside triphosphate (dNTP) levels inside the cell is essential for optimal fidelity of DNA replication. Ribonucleotide reductase (RNR) is the enzyme responsible for proportional production of...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_US |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1957/31161 |