Active site studies and design of ligands for affinity column separation of 2,5-dihydroxyacetanilide epoxidase (DHAE) I and II
A series of compounds, 7-8 and 20-25, were tested as competitive inhibitors of 2,5-dihydroxyacetanilide epoxidase I (DHAE I) and DHAE II. A Hammett plot was constructed for each enzyme to determine the effect of electron density on inhibition. DHAE I gave a linear, highly correlated plot (r²=0.91) t...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_US |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1957/30151 |