| Summary: | This paper introduces an alternative technique for the development of
microfluidic systems for biotechnology based on mechanical machining and
ultrasonic welding. Advantages of this approach over existing prototyping
approaches involving the rapid development of tooling include: (a) short cycle
time, (b) design flexibility, and (c) low cost manufacturing. In addition, the process
provides a migration path to high volume production. A limitation of this system is
that it cannot practically produce microchannels smaller than about 250 μm (0.010
in). However, for many biological cell-based biosensors, this feature scale seems
well suited based on cell viability results. Several issues are discussed relevant to
this approach, including bond strength, seal leakage, and sterilization. === Graduation date: 2002
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