Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases
It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a consta...
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| Language: | en_US |
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2012
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| Online Access: | http://hdl.handle.net/1957/28973 |