Novel oligonucleotide-polymer conjugates: from carrier-free intracellular delivery to advanced architectures.
Many forms of oligonucleotides, such as antisense DNA, small interfering RNA, and aptamers, have been investigated as therapeutic agents with moderate but growing commercial success. Natural, unmodified nucleic acids exhibit unfavorable biopharmaceutical characteristics that greatly limit their rate...
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| Online Access: | http://hdl.handle.net/2047/D20316333 |