Surface engineered PEI-modified liposomes for combination treatment of drug-resistant cancers by co-delivery of siRNA and paclitaxel
Surface-modification of nanoparticles with PEG to confer stealth properties has been considered the most common practice for many years. However, controversial and serious challenges related to PEGylation have been identified, including lack of functionality, hindered cellular interaction, allergic...
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| Online Access: | http://hdl.handle.net/2047/D20292338 |
| Summary: | Surface-modification of nanoparticles with PEG to confer stealth properties has been considered the most common practice for many years. However, controversial and serious challenges related to PEGylation have been identified, including lack of functionality, hindered cellular interaction, allergic reactions, and stimulation of IgM production after repetitive dosing that accelerates blood clearance of nanoparticles. The development of alternative nanoparticle modifications has been encouraged to overcome these obstacles and improve therapeutic outcomes. |
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