In vitro evaluations of hexokinase-2 inhibition with 3-bromopyruvate encapsulated in targeted liposomal formulations using 3D spheroid models of tumor aerobic glycolysis
A huge unmet medical need exists in the treatment of ovarian cancer in developing efficacious therapies for the advanced stage patients without the burden of off-target toxicity. This is partly because the current in vitro monolayer cell cultures, which are used for anti-cancer drug development, don...
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| Online Access: | http://hdl.handle.net/2047/D20213394 |