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ndltd-NEU--neu-cj82n80902021-05-27T05:11:15ZState-of-art separation mass spectrometry in protein characterizationA therapeutic protein derived from recombinant DNA technology usually poses a high degree of complexity. A complete heterogeneity profile of the therapeutic protein is critical to ensure the quality, safety and efficacy of the drug. To achieve a complete mapping of all possible protein modifications including the various types of post-translational modifications and sequence variants, the incorporation of high resolution separation methods and high sensitivity detection techniques are required. The purpose of this dissertation is to develop and apply sensitive and robust mass spectrometry (MS)-based analytical platforms to address the challenges associated with protein identification and characterization.http://hdl.handle.net/2047/D20211688
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NDLTD
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| description |
A therapeutic protein derived from recombinant DNA technology usually poses a high degree of complexity. A complete heterogeneity profile of the therapeutic protein is critical to ensure the quality, safety and efficacy of the drug. To achieve a complete mapping of all possible protein modifications including the various types of post-translational modifications and sequence variants, the incorporation of high resolution separation methods and high sensitivity detection
techniques are required. The purpose of this dissertation is to develop and apply sensitive and robust mass spectrometry (MS)-based analytical platforms to address the challenges associated with protein identification and characterization.
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| title |
State-of-art separation mass spectrometry in protein characterization
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| spellingShingle |
State-of-art separation mass spectrometry in protein characterization
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| title_short |
State-of-art separation mass spectrometry in protein characterization
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| title_full |
State-of-art separation mass spectrometry in protein characterization
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| title_fullStr |
State-of-art separation mass spectrometry in protein characterization
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| title_full_unstemmed |
State-of-art separation mass spectrometry in protein characterization
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state-of-art separation mass spectrometry in protein characterization
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http://hdl.handle.net/2047/D20211688
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1719407137148370944
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