GTP hydrolysis in RAS: how mutations affect hydrogen bonding and catalysis.
RAS GTPases (H, K and NRAS) are closely related membrane associated GTP binding proteins (95% sequence identity) that participate in numerous cell signaling processes, including cellular proliferation and survival. RAS functions as a binary switch, where in the GDP bound form it is signaling inactiv...
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| Online Access: | http://hdl.handle.net/2047/D20211606 |