Novel biophotonic imaging concepts: signal processing algorithms and hardware implementation.

• Online Access: http://hdl.handle.net/2047/D20200474

In this work, we consider the development of novel biophotonic imaging concepts from both a signal processing and hardware perspective. With respect to the former, we employ classic and recent signal processing approaches to (1) explore the optimization of system design for a novel time-domain hyperspectral tomographic imager; and (2) develop novel, intrinsically-regularized algorithms for the processing of fluorescence molecular tomography (FMT) data from two instrument prototypes. With respect to the latter, we consider the construction of a custom microscope to be used for label-free enumeration and characterization of circulating cells in vivo.