Design and synthesis of methionine analogues for the enzymatic synthesis of S-adenosyl-methionine analogues: tools for the analysis of methyltransferase substrate specificity.
Determining enzyme-substrate specificity is tantamount to understanding biology on a molecular level. In medicinal chemistry, for example, this is often the crucial starting point from which a drug discovery project emanates. Understanding specificity can be a markedly difficult task, however, espec...
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| Online Access: | http://hdl.handle.net/2047/d20002527 |