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ndltd-NEU--neu-727
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oai_dc
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ndltd-NEU--neu-7272021-05-26T05:10:32ZEndocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.The endocannabinoid system includes signaling ligands for the cannabinoid receptors, (CB1, CB2) as well as the enzymes that that are responsible for their biosynthesis and degradation. The two primary endogenous ligands N-arachidonoylethanolamine (AEA) and (2-AG) interact with the CB receptors similar to Δ9-tetrahydrocannabinol (THC), a classical cannabinoid isolated from the Cannabis sativa plant. The endocannabinoids AEA and 2-AG are released "on demand" by neurons in the brain as well as in peripheral tissues. Manipulating the concentration of these signaling molecules is an important area of investigation as significant therapeutic benefits are anticipated.http://hdl.handle.net/2047/d20002760
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NDLTD
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NDLTD
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| description |
The endocannabinoid system includes signaling ligands for the cannabinoid receptors, (CB1, CB2) as well as the enzymes that that are responsible for their biosynthesis and degradation. The two primary endogenous ligands N-arachidonoylethanolamine (AEA) and (2-AG) interact with the CB receptors similar to Δ9-tetrahydrocannabinol (THC), a classical cannabinoid isolated from the Cannabis sativa plant. The endocannabinoids AEA and 2-AG are released "on demand" by neurons in the
brain as well as in peripheral tissues. Manipulating the concentration of these signaling molecules is an important area of investigation as significant therapeutic benefits are anticipated.
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| title |
Endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.
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| spellingShingle |
Endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.
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| title_short |
Endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.
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| title_full |
Endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.
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| title_fullStr |
Endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.
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| title_full_unstemmed |
Endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.
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| title_sort |
endocannabinoid enzymes monoacylglycerol lipase and diacylglycerol lipase: biochemical studies and novel ligands.
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| url |
http://hdl.handle.net/2047/d20002760
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| _version_ |
1719406401939308544
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