Spectral cytopathology: infrared micro-spectroscopy of human cells.
Spectral Cytopathology (SCP) is a novel application of Fourier transform infrared micro-spectroscopy (IR-MSP) for use as a diagnostic tool for the objective and reproducible screening for cervical cancers. SCP couples IR-MSP with unsupervised multivariate statistical methods of analysis, and is capa...
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| Online Access: | http://hdl.handle.net/2047/d20000947 |
| Summary: | Spectral Cytopathology (SCP) is a novel application of Fourier transform infrared micro-spectroscopy (IR-MSP) for use as a diagnostic tool for the objective and reproducible screening for cervical cancers. SCP couples IR-MSP with unsupervised multivariate statistical methods of analysis, and is capable of detecting spectral patterns related to intrinsic molecular changes within individual exfoliated cells that are unique to maturation state, hormonal influence, viral
infection, and disease. Spectral differences within individual cells may reveal biochemical changes that may be precursors to cancer before they are reflected in the morphology of the cell. |
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