Determining the enzymatic mechanism for human AP endonuclease on a natural substrate
Human AP endonuclease (Ape1) is a DNA repair protein responsible for the 5ʹ cleavage of abasic sites (AP sites), a major form of DNA damage. The multi-functional DNA repair protein also plays a role in cancer resistance to DNA damaging chemotherapeutics. This lab has shown that the enzyme cleaves a...
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| Online Access: | http://hdl.handle.net/2047/d20002579 |