Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation

Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation

Knowledge of the active site is the first step to understanding the function of an enzyme. My research encompassed the use of electrostatics-based computational functional site prediction methods, Theoretical Microscopic Anomalous Titration Curve Shapes (THEMATICS) and Partial Order Optimum Likeliho...

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Online Access:http://hdl.handle.net/2047/d20005099
id ndltd-NEU--neu-336289
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spelling ndltd-NEU--neu-3362892021-05-25T05:10:24ZElectrostatics-based computational methods for understanding polymerase mechanism and for protein function annotationKnowledge of the active site is the first step to understanding the function of an enzyme. My research encompassed the use of electrostatics-based computational functional site prediction methods, Theoretical Microscopic Anomalous Titration Curve Shapes (THEMATICS) and Partial Order Optimum Likelihood (POOL) to understand the role of active site and distal residues in a polymerase and also to develop a methodology to classify the members of protein superfamilies according to biochemical function and thus to annotate proteins of unknown function.http://hdl.handle.net/2047/d20005099
collection NDLTD
sources NDLTD
description Knowledge of the active site is the first step to understanding the function of an enzyme. My research encompassed the use of electrostatics-based computational functional site prediction methods, Theoretical Microscopic Anomalous Titration Curve Shapes (THEMATICS) and Partial Order Optimum Likelihood (POOL) to understand the role of active site and distal residues in a polymerase and also to develop a methodology to classify the members of protein superfamilies according to biochemical function and thus to annotate proteins of unknown function.
title Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation
spellingShingle Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation
title_short Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation
title_full Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation
title_fullStr Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation
title_full_unstemmed Electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation
title_sort electrostatics-based computational methods for understanding polymerase mechanism and for protein function annotation
publishDate
url http://hdl.handle.net/2047/d20005099
_version_ 1719406132068352000

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