impact of cellular networks on disease comorbidity

The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease-...

Full description

Bibliographic Details
Published:
Online Access:http://hdl.handle.net/2047/d20000682
id ndltd-NEU--neu-331054
record_format oai_dc
spelling ndltd-NEU--neu-3310542016-04-25T16:14:18Zimpact of cellular networks on disease comorbidityThe impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease-gene associations, and population-level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease comorbidity patterns in the human population. Our results indicate that such a combination of population-level data and cellular network information could help build novel hypotheses about disease mechanisms.http://hdl.handle.net/2047/d20000682
collection NDLTD
sources NDLTD
description The impact of disease-causing defects is often not limited to the products of a mutated gene but, thanks to interactions between the molecular components, may also affect other cellular functions, resulting in potential comorbidity effects. By combining information on cellular interactions, disease-gene associations, and population-level disease patterns extracted from Medicare data, we find statistically significant correlations between the underlying structure of cellular networks and disease comorbidity patterns in the human population. Our results indicate that such a combination of population-level data and cellular network information could help build novel hypotheses about disease mechanisms.
title impact of cellular networks on disease comorbidity
spellingShingle impact of cellular networks on disease comorbidity
title_short impact of cellular networks on disease comorbidity
title_full impact of cellular networks on disease comorbidity
title_fullStr impact of cellular networks on disease comorbidity
title_full_unstemmed impact of cellular networks on disease comorbidity
title_sort impact of cellular networks on disease comorbidity
publishDate
url http://hdl.handle.net/2047/d20000682
_version_ 1718235714050588672