Cysteine dependence of insulin-like growth factor effects on redox and methylation status

• Online Access: http://hdl.handle.net/2047/d20002964

Methionine synthase serves as a bridge between the methionine cycle and the dopamine-stimulated phospholipid methylation cycle. Cobalamin is the co-factor of methionine synthase to catalyze the conversion of homocysteine to methionine. Oxidized cobalamin halts methionine synthase activity, increasing homocysteine diversion to the transsulfuration pathway leading to formation of cysteine which can then be converted to the primary intracellular antioxidant glutathione.