Hypoxia in tumor angiogenesis and metastasis: evaluation of VEGF and MMP over-expression and down-regulation of HIF-1α with RNAi in hypoxic tumor cells.
Background: As tumor mass grows beyond a few millimeters in diameter, the angiogenic "switch" is turned on leading to recruitment of blood vessels from surrounding artery and veins. However, the tumor mass is poorly perfused and there are pockets of hypoxia or lower oxygen concentrations r...
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| Online Access: | http://hdl.handle.net/2047/d20000811 |