| Summary: | The undesired side-effects of many therapies and diagnostics result from their accumulation in the non-target tissues. There is a clear need to design pharmaceutical delivery systems capable of delivering drugs, DNA and diagnostics to the target tissue with minimal accumulation in the non-target tissues. Targeted delivery of pharmaceuticals will help in reducing accumulation and undesired side-effects in the non-target organs, and increase the amount of drug delivered and
drug bioavailability at intended target organs. Targeting can be achieved passively by long circulation time of the pharmaceuticals in the blood, actively by using target-specific ligands or by combination of both. The major long term goal of this project is to develop optimal delivery systems capable of delivering drugs, DNA or imaging agents to the intended target site using polymeric carriers like dextran, or nanoparticulate carriers like liposomes and micelles.
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