Design and synthesis of novel cannabinergic analogs with controlled detoxification

Cannabis has been used medicinally and recreationally for several centuries, commonly in the form of the plant's dried leaf/flower ("marijuana"). Δ9- Tetrahydrocannabinol (Δ9-THC) is the primary psychoactive component of cannabis and is prescribed as a pharmaceutical (Dronabinol®) to...

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spelling ndltd-NEU--neu-17412021-05-25T05:10:10ZDesign and synthesis of novel cannabinergic analogs with controlled detoxificationCannabis has been used medicinally and recreationally for several centuries, commonly in the form of the plant's dried leaf/flower ("marijuana"). Δ9- Tetrahydrocannabinol (Δ9-THC) is the primary psychoactive component of cannabis and is prescribed as a pharmaceutical (Dronabinol®) to stimulate appetite in AIDS patients, and to treat nausea and vomiting for patients undergoing chemotherapy. Δ9-THC is also under clinical investigation as an agonist-based therapy to combat cannabis dependence and addiction. Nabilone® is a synthetic Δ9-THC analog sold as a prescription medication for treating emesis and as an analgesic for neuropathic pain. However, Dronabinol® and Nabilone® therapies suffer from several drawbacks, including unpredictable duration of action, poor bioavailability, and variable efficacy and detoxification, primarily due to high lipophilicity and the production of pharmacologically active metabolites after metabolic biotransformation.http://hdl.handle.net/2047/d20002953
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description Cannabis has been used medicinally and recreationally for several centuries, commonly in the form of the plant's dried leaf/flower ("marijuana"). Δ9- Tetrahydrocannabinol (Δ9-THC) is the primary psychoactive component of cannabis and is prescribed as a pharmaceutical (Dronabinol®) to stimulate appetite in AIDS patients, and to treat nausea and vomiting for patients undergoing chemotherapy. Δ9-THC is also under clinical investigation as an agonist-based therapy to combat cannabis dependence and addiction. Nabilone® is a synthetic Δ9-THC analog sold as a prescription medication for treating emesis and as an analgesic for neuropathic pain. However, Dronabinol® and Nabilone® therapies suffer from several drawbacks, including unpredictable duration of action, poor bioavailability, and variable efficacy and detoxification, primarily due to high lipophilicity and the production of pharmacologically active metabolites after metabolic biotransformation.
title Design and synthesis of novel cannabinergic analogs with controlled detoxification
spellingShingle Design and synthesis of novel cannabinergic analogs with controlled detoxification
title_short Design and synthesis of novel cannabinergic analogs with controlled detoxification
title_full Design and synthesis of novel cannabinergic analogs with controlled detoxification
title_fullStr Design and synthesis of novel cannabinergic analogs with controlled detoxification
title_full_unstemmed Design and synthesis of novel cannabinergic analogs with controlled detoxification
title_sort design and synthesis of novel cannabinergic analogs with controlled detoxification
publishDate
url http://hdl.handle.net/2047/d20002953
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