Lipid-based systems for delivery of drugs and siRNA

• Online Access: http://hdl.handle.net/2047/d20002947

Fundamental progress in cancer biology has resulted in remarkable advances in cancer therapy. The goal now is to translate this knowledge in effective therapies. The major problem in cancer therapy is targeting the tumor site efficaciously and avoiding the undesired side effects at non-target sites. Nanocarriers like liposomes and micelles help to enhance delivery of therapeutics, influence the pharmacokinetic profile, drug metabolism and promote accumulation of the drug in the pathological area. The major long term goal of this project was to develop optimal delivery systems, capable of delivering small drug molecules like ascorbate and biotherapeutics like small interfering RNA (siRNA), using nanoparticles like liposomes and micelles.