Development of cell-specific and organelle-specific delivery systems by surface modification of lipid-based pharmaceutical nanocarriers
The use of lipid-based pharmaceutical nanocarriers, such as lipid-core polymeric micelles and liposomes have improved the pharmacokinetic and pharmacodynamic properties of many pharmaceuticals, especially in chemotherapy. These delivery systems have not only helped in increasing the solubility of po...
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| Online Access: | http://hdl.handle.net/2047/d20002485 |
| Summary: | The use of lipid-based pharmaceutical nanocarriers, such as lipid-core polymeric micelles and liposomes have improved the pharmacokinetic and pharmacodynamic properties of many pharmaceuticals, especially in chemotherapy. These delivery systems have not only helped in increasing the solubility of poorly soluble chemotherapeutic drugs but have also acted as reservoir of large molecular weight active pharmaceutical ingredients (API) like proteins. The objective of the thesis
was to explore surface modification options to further enhance the delivery of pro-apoptotic small molecules for cell-specific delivery and proteins for intracellular delivery. The thesis has been divided into two sections. |
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